Peskind E R, Elrod R, Dobie D J, Pascualy M, Petrie E, Jensen C, Brodkin K, Murray S, Veith R C, Raskind M A
VA Puget Sound Health Care System, Mental Illness Research, Education, and Clinical Center, Seattle, WA 98108, USA.
Neuropsychopharmacology. 1998 Dec;19(6):465-71. doi: 10.1016/S0893-133X(98)00054-2.
Central nervous system (CNS) adrenergic systems are involved in regulation of behavior and blood pressure. The effects of Alzheimer's disease (AD) and normal aging on resting CNS adrenergic activity were estimated by measuring cerebrospinal fluid (CSF) epinephrine (EPI) concentrations in 74 persons with AD, 42 cognitively normal healthy older persons, and 54 healthy young persons. The responsiveness of CSF EPI to the alpha-2 adrenergic antagonist yohimbine and the alpha-2 adrenergic agonist clonidine was measured in smaller subject groups. Resting CSF EPI was higher in AD than in older or young subjects, and increased with dementia severity in AD subjects. There was no relationship between resting CSF EPI and blood pressure. CSF EPI increased following yohimbine in AD and older subjects but not in young subjects. CSF EPI was unaffected by clonidine in all subject groups. The agitation increase following yohimbine was substantially greater in AD subjects than in older or young subjects. CNS adrenergic activity seems increased in AD, may further increase as AD progresses, and may be involved in the pathophysiology of agitation.
中枢神经系统（CNS）肾上腺素能系统参与行为和血压的调节。通过测量74例阿尔茨海默病（AD）患者、42例认知正常的健康老年人和54例健康年轻人的脑脊液（CSF）肾上腺素（EPI）浓度，评估了AD和正常衰老对静息CNS肾上腺素能活性的影响。在较小的受试者组中测量了CSF EPI对α-2肾上腺素能拮抗剂育亨宾和α-2肾上腺素能激动剂可乐定的反应性。AD患者静息CSF EPI高于老年或年轻受试者，且在AD患者中随痴呆严重程度增加。静息CSF EPI与血压之间无相关性。AD和老年受试者在注射育亨宾后CSF EPI升高，而年轻受试者则无此现象。所有受试者组的CSF EPI均不受可乐定影响。AD患者注射育亨宾后激越增加的幅度明显大于老年或年轻受试者。CNS肾上腺素能活性在AD中似乎增加，可能随着AD进展而进一步升高，并且可能参与激越的病理生理学过程。
