Omulokoli E, Khan B, Chhabra S C
Chemistry Department, Kenyatta University, Nairobi, Kenya.
J Ethnopharmacol. 1997 Apr;56(2):133-7. doi: 10.1016/s0378-8741(97)01521-3.
A preliminary antiplasmodial and phytochemical screening of four Kenyan medicinal plants was carried out. The medicinal plants were extracted and tested for in vitro antiplasmodial activity against chloroquine-sensitive (K67) and chloroquine-resistant (ENT36) strains of Plasmodium falciparum. Out of 16 extracts, 12 were active against ENT36 strain while seven were active against K67 strain, that is, IC50 < or = 50 micrograms/ml. The most active extracts on both strains were those of leaves of Phyllanthus reticulatus Poir, and Suregada zanzibariensis Baill. (Euphorbiaceae) with IC50 < or = 10 micrograms/ml. The stembark of Terminalia spinosa Engl. (Combretaceae) and the stems of Dissotis brazzae Cogn. (Melastomataceae) had IC50 < or = 10 micrograms/ml for strains K67 and ENT36, respectively. A preliminary phytochemical analysis of these plants revealed the presence of different classes of primary and secondary metabolites.
对四种肯尼亚药用植物进行了初步的抗疟原虫和植物化学筛选。对这些药用植物进行提取，并测试其对恶性疟原虫氯喹敏感株（K67）和氯喹耐药株（ENT36）的体外抗疟原虫活性。在16种提取物中，12种对ENT36株有活性，7种对K67株有活性，即半数抑制浓度（IC50）≤50微克/毫升。对两种菌株活性最强的提取物是网纹叶下珠（Phyllanthus reticulatus Poir）的叶提取物和桑给巴尔银柴（Suregada zanzibariensis Baill.，大戟科）的叶提取物，其IC50≤10微克/毫升。尖叶榄仁（Terminalia spinosa Engl.，使君子科）的茎皮提取物和巴西锦香草（Dissotis brazzae Cogn.，野牡丹科）的茎提取物对K67株和ENT36株的IC50分别≤10微克/毫升。对这些植物进行的初步植物化学分析表明存在不同类别的初级和次级代谢产物。
