Wanyoike G N, Chhabra S C, Lang'at-Thoruwa C C, Omar S A
Chemistry Department, School of Pure & Applied Sciences, Kenyatta University, 00100 GPO, PO Box 43844, Nairobi, Kenya.
J Ethnopharmacol. 2004 Jan;90(1):129-33. doi: 10.1016/j.jep.2003.09.047.
The organic extracts of leaves and roots of five plants used for treating malaria in Central, Nairobi and Rift Valley Provinces, Kenya were tested for brine shrimp lethality and in vitro antiplasmodial activity against chloroquine sensitive and resistant strains of Plasmodium falciparum. Of the plants tested, 60% were toxic to the brine shrimp (LC(50)<30 microg/ml) and eight out of ten plant parts (80%) showed in vitro antiplasmodial activity (IC(50)<50 microg/ml). Among the extracts screened, the leaves of Cyathula polcephala had the highest toxicity to the brine shrimp (LC(50)=2.9 microg/ml) while the leaves of Pentas longiflora had the best antiplasmodial activity (IC(50)=11. /ml). The plant extracts with low IC(50) values are potential sources for novel antiplasmodial compounds.
对肯尼亚中部、内罗毕和裂谷省用于治疗疟疾的五种植物的叶和根的有机提取物进行了卤虫致死性测试，以及对恶性疟原虫氯喹敏感和耐药菌株的体外抗疟活性测试。在所测试的植物中，60% 对卤虫有毒（半数致死浓度<30微克/毫升），十分之八（80%）的植物部位表现出体外抗疟活性（半数抑制浓度<50微克/毫升）。在筛选的提取物中，多穗杯苋的叶对卤虫毒性最高（半数致死浓度 = 2.9微克/毫升），而长花五星花的叶抗疟活性最佳（半数抑制浓度 = 11./毫升）。半数抑制浓度值低的植物提取物是新型抗疟化合物的潜在来源。
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