长叶五层龙（Salacia oblonga Wall.）和刺茉莉（Azima tetracantha Lam.）的抗炎活性
Anti-inflammatory activity of Salacia oblonga Wall. and Azima tetracantha Lam.
作者信息
Ismail T S, Gopalakrishnan S, Begum V H, Elango V
机构信息
Department of Chemistry, Manonmaniam Sundaranar University, Tamil Nadu, India.
出版信息
J Ethnopharmacol. 1997 Apr;56(2):145-52. doi: 10.1016/s0378-8741(96)01523-1.
The anti-inflammatory activity of Salacia oblonga rootbark powder and Azima tetracantha leaf powder was assayed in male albino rats using carrageenan-induced rat paw oedema (acute inflammation) and cotton pellet granuloma (chronic inflammation) methods. Both the crude drugs were maximally active at a dose of 1000 mg/kg. In the cotton pellet granuloma assay, these drugs were able to suppress the transudative, exudative and proliferative components of chronic inflammation. Furthermore, these drugs were able to lower the lipid peroxide content of exudate and liver, gamma-glutamyl transpeptidase activity in the exudate of cotton pellet granuloma. The increased acid and alkaline phosphatase activity and decreased serum albumin in cotton pellet granulomatous rats were normalised after treatment with these drugs. It is likely that these drugs may exert their activity by antiproliferative, antioxidative and lysosomal membrane stabilization.
使用角叉菜胶诱导的大鼠爪肿胀（急性炎症）和棉球肉芽肿（慢性炎症）方法，在雄性白化病大鼠中测定了长柄盐肤木根皮粉和四刺刺茉莉叶粉的抗炎活性。两种粗药在剂量为1000mg/kg时活性最大。在棉球肉芽肿试验中，这些药物能够抑制慢性炎症的渗出、渗出和增殖成分。此外，这些药物能够降低渗出液和肝脏的脂质过氧化物含量、棉球肉芽肿渗出液中的γ-谷氨酰转肽酶活性。用这些药物治疗后，棉球肉芽肿大鼠中酸性和碱性磷酸酶活性增加以及血清白蛋白降低的情况恢复正常。这些药物可能通过抗增殖、抗氧化和溶酶体膜稳定作用发挥其活性。
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