Siegan J B, Hama A T, Sagen J
Department of Anatomy and Cell Biology, University of Illinois at Chicago, 60612, USA.
Brain Res. 1997 May 2;755(2):331-4. doi: 10.1016/s0006-8993(97)00183-2.
Chronic pain may result from hyperexcitability following activation of spinal NMDA receptors. A naturally-derived mammalian peptide, histogranin, may possess NMDA antagonist activity. This study explored the possibility that stable analog [Ser1]Histogranin (SHG) could reduce chronic pain. Neuropathic pain was induced using the chronic constriction injury model (CCI). Intrathecal injection of SHG markedly attenuated the hyperalgesia and allodynia resulting from CCI, nearly normalizing responses. These results suggest that the natural peptide histogranin may be a novel adjunct in neuropathic pain management.
慢性疼痛可能源于脊髓NMDA受体激活后的过度兴奋。一种天然衍生的哺乳动物肽，组织颗粒蛋白，可能具有NMDA拮抗剂活性。本研究探讨了稳定类似物[Ser1]组织颗粒蛋白（SHG）减轻慢性疼痛的可能性。使用慢性压迫损伤模型（CCI）诱导神经性疼痛。鞘内注射SHG可显著减轻CCI引起的痛觉过敏和异常性疼痛，使反应几乎恢复正常。这些结果表明，天然肽组织颗粒蛋白可能是神经性疼痛管理中的一种新型辅助药物。
