Maillé A R, Koning C J, Zwinderman A H, Willems L N, Dijkman J H, Kaptein A A
Department of Psychiatry, University of Leiden, Oegstgeest, The Netherlands.
Respir Med. 1997 May;91(5):297-309. doi: 10.1016/s0954-6111(97)90034-2.
Chronic non-specific lung disease (CNSLD) encompasses asthma as well as chronic obstructive pulmonary disease (COPD). Recently in health care, there has been increasing awareness in the functional, psychological and social aspects of the health of patients; their quality of life (QOL). Quality-of-life research addressing CNSLD patients has been rather underdeveloped for a long period of time. Recently, however, the importance of QOL is being increasingly recognized, and several research groups have started to study QOL in CNSLD patients in more detail. This paper describes the construction of a disease-specific QOL instrument for patients with mild to moderately severe CNSLD. Items relating to several domains of QOL were listed, and 171 CNSLD patients in general practice were asked how much of a problem each item had been (assessed on a seven-point Likert scale). After applying an item-selection procedure, a uni-dimensional QOL questionnaire was constructed consisting of 55 items divided into seven domain subscales: breathing problems, physical problems, emotions, situations triggering or enhancing breathing problems, general activities, daily and domestic activities, and social activities, relationships and sexuality. Reliability estimates of the domain subscales of the constructed questionnaire varied from 0.68 to 0.89, and was 0.92 for the QOL for Respiratory Illness Questionnaire (QOL-RIQ) total scale. A first impression of the construct validity of the questionnaire was gained by investigation of the relationship between the QOL domain subscales and several indicators of illness severity, as well as the relative contribution of illness severity variables, background characteristics and symptoms to QOL, using regression analysis. Further research to validate the questionnaire to a greater extent (construct validity, test-retest reliability and responsiveness to change) is currently taking place.
慢性非特异性肺部疾病（CNSLD）包括哮喘以及慢性阻塞性肺疾病（COPD）。近年来，在医疗保健领域，人们越来越关注患者健康在功能、心理和社会方面的状况，即他们的生活质量（QOL）。长期以来，针对CNSLD患者的生活质量研究一直相当滞后。然而，近来生活质量的重要性日益得到认可，一些研究团队已开始更深入地研究CNSLD患者的生活质量。本文描述了一种针对轻度至中度严重CNSLD患者的疾病特异性生活质量评估工具的构建过程。列出了与生活质量几个领域相关的项目，并询问了171名全科医疗中的CNSLD患者每个项目所造成问题的程度（采用七点李克特量表进行评估）。在应用项目筛选程序后，构建了一份单维度生活质量问卷，该问卷由55个项目组成，分为七个领域子量表：呼吸问题、身体问题、情绪、引发或加重呼吸问题的情况、一般活动、日常和家庭活动以及社交活动、人际关系和性方面。所构建问卷的领域子量表的信度估计值在0.68至0.89之间，呼吸疾病生活质量问卷（QOL - RIQ）总量表的信度为0.9
