食欲兴奋剂赛庚啶对脱氧雪腐镰刀菌烯醇诱导的小鼠采食量和体重增加减少的影响。
Effect of the appetite stimulant cyproheptadine on deoxynivalenol-induced reductions in feed consumption and weight gain in the mouse.
作者信息
Prelusky D B, Rotter B A, Thompson B K, Trenholm H L
机构信息
Centre for Food and Animal Research Agriculture and Agri-Food Canada Ottawa, Ontario, Canada.
出版信息
J Environ Sci Health B. 1997 May;32(3):429-48. doi: 10.1080/03601239709373096.
Deoxynivalenol (DON, vomitoxin), a Fusarium mycotoxin, is suspected of inducing its anorectic/feed refusal activity through a serotoninergic (5HT) mechanism, possible via 5HT2-receptors. In this study the efficiency of cyproheptadine (CYP), a serotonin antagonist and known appetite stimulant, to attenuate the adverse effect of DON was investigated in mice. CYP was administered in the feed for two days before animals began receiving the DON, which was also added to the feed. Both agents were administered concurrently thereafter for a 12-day period. Dosing levels included various combinations of the two compounds, ranging from 0-16 ppm DON and 0-20 ppm CYP.
脱氧雪腐镰刀菌烯醇（DON，呕吐毒素）是一种镰刀菌属霉菌毒素，据推测它通过5-羟色胺能（5HT）机制引发其厌食/拒食活性，可能是通过5HT2受体。在本研究中，在小鼠身上研究了血清素拮抗剂、已知的食欲刺激剂赛庚啶（CYP）减轻DON不良影响的效果。在动物开始摄入添加到饲料中的DON之前，先在饲料中添加CYP两天。此后，两种药剂同时给药12天。给药水平包括两种化合物的各种组合，DON浓度范围为0 - 16 ppm，CYP浓度范围为0 - 20 ppm。
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