Rotter B A, Prelusky D B, Thompson B K
Centre for Food and Animal Research, Agriculture and Agri-Food Canada, Ottawa, Ontario, Canada.
J Environ Sci Health B. 1996 Nov;31(6):1279-88. doi: 10.1080/03601239609373067.
Deoxynivalenol (DON, vomitoxin) commonly produced by Fusarium fungi can alter feeding behaviour of pigs and other farm animals. The effects of dietary tryptophan (TRP, precursor of brain amine serotonin) in combination with DON were examined in mice to determine if TRP can modulate DON toxicity. Results indicated that brain TRP can be influenced by dietary TRP, but no evidence of TRP potentiating DON toxicity was observed. Higher TRP levels likely induced amino acid imbalance leading to weight gain suppression.
脱氧雪腐镰刀菌烯醇(DON,呕吐毒素)通常由镰刀菌属真菌产生,可改变猪和其他农场动物的摄食行为。在小鼠中研究了膳食色氨酸(TRP,脑胺血清素的前体)与DON联合使用的效果,以确定TRP是否能调节DON的毒性。结果表明,膳食TRP可影响脑内TRP,但未观察到TRP增强DON毒性的证据。较高的TRP水平可能导致氨基酸失衡,从而抑制体重增加。