Ras1介导的果蝇同源功能在细胞和体节身份中的调控。
Ras1-mediated modulation of Drosophila homeotic function in cell and segment identity.
作者信息
Boube M, Benassayag C, Seroude L, Cribbs D L
机构信息
CBD-CNRS, Toulouse, France.
出版信息
Genetics. 1997 Jun;146(2):619-28. doi: 10.1093/genetics/146.2.619.
Abstract
Mutations of the Drosophila homeotic proboscipedia gene (pb, the Hox-A2/B2 homologue) provoke dose-sensitive defects. These were used to search for dose-sensitive dominant modifiers of pb function. Two identified interacting genes were the proto-oncogene Ras1 and its functional antagonist Gap1, prominent intermediaries in known signal transduction pathways. Ras1+ is a positive modifier of pb activity both in normal and ectopic cell contexts, while the Ras1-antagonist Gap1 has an opposite effect. A general role for Ras1 in homeotic function is likely, since Ras1+ activity also modulates functions of the homeotic loci Sex combs reduced and Ultrabithorax. Our data suggest that the modulation occurs by a mechanism independent of transcriptional control of the homeotic loci themselves, or of the Ras1/Gap1 genes. Taken together our data support a role for Ras1-mediated cell signaling in the homeotic control of segmental differentiation.
摘要
果蝇同源异型基因触须基因（pb，Hox-A2/B2 同源物）的突变会引发剂量敏感缺陷。这些缺陷被用于寻找 pb 功能的剂量敏感显性修饰因子。鉴定出的两个相互作用基因是原癌基因 Ras1 及其功能拮抗剂 Gap1，它们是已知信号转导途径中的重要中介物。Ras1+ 在正常和异位细胞环境中都是 pb 活性的正向修饰因子，而 Ras1 的拮抗剂 Gap1 则有相反的作用。Ras1 在同源异型功能中可能具有普遍作用，因为 Ras1+ 活性也调节同源异型基因座性别梳减少和超双胸的功能。我们的数据表明，这种调节是通过一种独立于同源异型基因座本身或 Ras1/Gap1 基因转录控制的机制发生的。综合来看，我们的数据支持 Ras1 介导的细胞信号传导在节段分化的同源异型控制中的作用。
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