Lai H M, Davie C A, Gass A, Barker G J, Webb S, Tofts P S, Thompson A J, McDonald W I, Miller D H
MS and NMR Research Unit, Institute of Neurology, London, UK.
J Neurol. 1997 May;244(5):308-11. doi: 10.1007/s004150050092.
The magnetisation transfer (MT) ratio of eight multiple sclerosis lesions has been studied serially. Initially, when the lesions showed gadolinium enhancement, there was a marked reduction in their MT ratio compared with normal white matter. Follow-up a mean of 11 months later (range 3-23 months), when the lesions no longer enhanced, revealed a consistent and usually marked recovery of the MT ratios towards normal. The MT ratio is thought to reflect the structural integrity of tissues with an important contribution from myelin and axons. MT imaging is a promising tool for elucidating pathophysiology and monitoring treatment in multiple sclerosis.
对八个多发性硬化症病灶的磁化传递（MT）比率进行了连续研究。最初，当病灶显示钆增强时，与正常白质相比，其MT比率显著降低。平均11个月后（范围3 - 23个月）进行随访，此时病灶不再增强，结果显示MT比率持续且通常显著恢复至正常水平。MT比率被认为反映了组织的结构完整性，其中髓鞘和轴突起到重要作用。MT成像对于阐明多发性硬化症的病理生理学和监测治疗是一种很有前景的工具。
