De Serres G, Joly J R, Fauvel M, Meyer F, Mâsse B, Boulianne N
Centre de Santé Publique de Québec, Beauport, Canada.
Vaccine. 1997 Apr-May;15(6-7):620-3. doi: 10.1016/s0264-410x(96)00283-6.
Neutralizing antibody titers of 47 infants whose mothers sustained measles (measles group) and 70 whose mothers were vaccinated (vaccine group) were compared at birth, 4 and 8 months of age. All children had antibodies at birth and 88% at 4 months. At 8 months, 49% had antibodies in the measles group and 15% in the vaccine group (P < 0.001). The geometric mean titers were significantly lower in the vaccine group than in the measles group and the difference corresponded to the antibody loss occurring in only 1.5 months of life. This small difference may reflect past exposure to wild virus of many vaccinated mothers.
对47名母亲患麻疹的婴儿（麻疹组）和70名母亲接种过疫苗的婴儿（疫苗组）在出生时、4个月和8个月大时的中和抗体滴度进行了比较。所有儿童在出生时均有抗体，4个月时88%有抗体。8个月时，麻疹组49%有抗体，疫苗组15%有抗体（P<0.001）。疫苗组的几何平均滴度显著低于麻疹组，这种差异相当于在仅1.5个月的生命中发生的抗体丧失。这种微小差异可能反映了许多接种过疫苗的母亲过去接触过野生病毒。
