Dagli M L, Calderaro F F, Silva M T, Guerra J L
Department of Pathology, Faculty of Veterinary Medicine and Zootechny, University of São Paulo, Brazil.
J Comp Pathol. 1997 May;116(4):397-402. doi: 10.1016/s0021-9975(97)80056-4.
The gross and microscopical features of a squamous cell carcinoma of the renal pelvis in an 18-year-old dog are described. This is a rare tumour originating from transitional cells of the pelvis. The tumour, which invaded the renal parenchyma and capsule and the small intestinal wall, metastasized to the lungs. Tumour cells expressed cytokeratin 8 and were arranged in a pattern similar to that of a squamous cell carcinoma found elsewhere, with prickle cells and horny pearls. The tumour was not diagnosed clinically but was found at necropsy. The presence of pelvic calculi in this dog is suggested as a cause of transitional cell squamous metaplasia and malignant transformation.
描述了一只18岁犬肾盂鳞状细胞癌的大体和显微镜特征。这是一种起源于肾盂移行细胞的罕见肿瘤。该肿瘤侵犯了肾实质、肾包膜和小肠壁，并转移至肺部。肿瘤细胞表达细胞角蛋白8，其排列方式与其他部位发现的鳞状细胞癌相似，有棘细胞和角化珠。该肿瘤生前未被诊断出来，而是在尸检时发现的。提示这只犬存在盆腔结石是移行细胞鳞状化生和恶性转化的原因。
