Rice D P, Roberts G J, Thomas M L
Department of Orthodontics and Paediatric Dentistry, UMDS of Guy's Hospital, London, UK.
Eur J Orthod. 1997 Apr;19(2):141-50. doi: 10.1093/ejo/19.2.141.
Immature Snell strain dwarf mice were treated with human growth hormone for 20 and 40 days, between the ages of 22 and 41 days and 22 and 61 days, respectively. Mature dwarfs were similarly treated for 20 and 40 days between the ages of 62 and 81 days and 62 and 101 days, respectively. These groups of treated mice were compared with untreated dwarfs and normal mice reared under the same conditions. The catch-up growth effected by human growth hormone on the craniofacial and somatic development of the Snell strain dwarf mouse at both immature and mature ages was considerable, overall being approximately 14 per cent. Neurocranial parameters tended toward the values of normal mice achieving 89-98 per cent of normal growth. Viscerocranial parameters showed greater catch-up, from a lower start point, reaching 81-93 per cent of the control. This catch-up in mature mice (aged 82-102 days) was at a time when any substantial growth in either dwarf or normal mice has usually ceased.
未成熟的斯内尔品系侏儒小鼠分别在22至41日龄以及22至61日龄期间，用人类生长激素处理20天和40天。成熟侏儒小鼠则分别在62至81日龄以及62至101日龄期间，同样用人类生长激素处理20天和40天。将这些接受处理的小鼠组与未处理的侏儒小鼠以及在相同条件下饲养的正常小鼠进行比较。人类生长激素对未成熟和成熟年龄的斯内尔品系侏儒小鼠的颅面和躯体发育所产生的追赶生长相当可观，总体约为14%。神经颅参数趋向于正常小鼠的值，达到正常生长的89%至98%。内脏颅参数显示出更大的追赶幅度，从较低的起点开始，达到对照的81%至93%。成熟小鼠（82至102日龄）的这种追赶生长发生在侏儒小鼠和正常小鼠通常已停止任何显著生长的时候。
