Lindgren A, Aldenborg F, Norkrans G, Olaison L, Olsson R
Department of Internal Medicine, University of Göteborg, Sahlgrenska Hospital, Sweden.
J Intern Med. 1997 May;241(5):435-9. doi: 10.1046/j.1365-2796.1997.117153000.x.
To describe uncommon (previously unreported) types of adverse liver reactions to paracetamol.
In addition to describing patients, with uncommon types of liver reactions to paracetamol, admitted to our hospitals, we surveyed all the liver reactions to paracetamol reported to the Swedish Adverse Drug Reactions Advisory Committee from 1973 to 1993.
The Swedish population of 8 million inhabitants.
Extensive medical evaluation.
We found one case with a cholestatic liver reaction and one with granulomatous hepatitis. The reactions were probably idiosyncratic and took several months to disappear.
In addition to the well-known dose-related toxic liver damage paracetamol may rarely cause non-dose-related severe, prolonged cholestasis or granulomatous hepatitis with cirrhosis.
描述对乙酰氨基酚罕见（此前未报道过）的肝脏不良反应类型。
除了描述我院收治的对乙酰氨基酚肝脏反应罕见类型的患者外，我们还调查了1973年至1993年向瑞典药物不良反应咨询委员会报告的所有对乙酰氨基酚肝脏反应。
瑞典有800万居民。
进行广泛的医学评估。
我们发现1例胆汁淤积性肝脏反应和1例肉芽肿性肝炎。这些反应可能是特异质性的，需要数月才能消失。
除了众所周知的与剂量相关的中毒性肝损伤外，对乙酰氨基酚还可能很少引起与剂量无关的严重、持续性胆汁淤积或伴有肝硬化的肉芽肿性肝炎。
