过敏性紫癜中的IgA免疫复合物。

IgA immune complexes in Henoch-Schönlein purpura.

作者信息

Levinsky R J, Barratt T M

出版信息

Lancet. 1979 Nov 24;2(8152):1100-3. doi: 10.1016/s0140-6736(79)92505-4.

Abstract

Raised levels of IgA immune complexes were found in 13 of 18 children with Henoch-Schönlein purpura irrespective of whether they developed nephritis or not. In contrast, only those children who developed nephritis had raised levels of IgG immune complexes as well. In 2 children with nephritis, two discrete peaks of IgA complexes were found, corresponding to 4 x 10(5) to 8 x 10(5) and 2.5 x 10(6) to 4 x 10(6) daltons. IgG complexes were found only in the larger-molecular-weight peak. Such differences in immune complexes may underlie the different manifestations of this disease.

摘要

在18例过敏性紫癜患儿中，有13例发现IgA免疫复合物水平升高，无论他们是否发展为肾炎。相比之下，只有那些发展为肾炎的儿童同时也有IgG免疫复合物水平升高。在2例患有肾炎的儿童中，发现了两个离散的IgA复合物峰，分别对应于4×10⁵至8×10⁵道尔顿和2.5×10⁶至4×10⁶道尔顿。IgG复合物仅在较大分子量的峰中发现。免疫复合物的这种差异可能是该疾病不同表现的基础。