Garcia-Fuentes M, Chantler C, Williams D G
Br Med J. 1977 Jul 16;2(6080):163-5. doi: 10.1136/bmj.2.6080.163.
Sera from patients with Henoch-Schönlein purpura were examined for cryoglobulinaemia. Thirty patients had acute Henoch-Schönlein purpura, with or without renal diseas; 14 had chronic nephritis after a previous episode of purpura; and 17 were well, without urinary abnormalities, after recovering from Henoch-Schönlen purpura. Raised concentrations of cryoglobulins were present in 14 (47%) of those with acute purpura, nine (64%) of those with chronic nephritis, but none of those who had recovered completely from Henoch-Schönlein purpura. This suggests that acute Henoch-Schönlein purpura and the chronic nephritis that sometimes follows it have an immune-complex pathogenesis. IgA and properdin were found in several cryoglobulins, which suggested that complement had been activated via the alternative pathway, but isolated cryoglobulins capable of splitting C3 in vitro did so via the classical pathway.
对过敏性紫癜患者的血清进行冷球蛋白血症检测。30例患者患有急性过敏性紫癜，伴有或不伴有肾脏疾病；14例在先前紫癜发作后患有慢性肾炎；17例在从过敏性紫癜康复后情况良好，无泌尿系统异常。急性紫癜患者中有14例（47%）冷球蛋白浓度升高，慢性肾炎患者中有9例（64%）冷球蛋白浓度升高，但从过敏性紫癜完全康复的患者中无一例冷球蛋白浓度升高。这表明急性过敏性紫癜以及有时随之而来的慢性肾炎具有免疫复合物发病机制。在几种冷球蛋白中发现了IgA和备解素，这表明补体已通过替代途径被激活，但能够在体外裂解C3的分离冷球蛋白是通过经典途径做到的。
