Morinet F
Service de microbiologie, Unité de virologie et CNRS UPR 9051, Hôpital Saint-Louis, Paris.
Rev Prat. 1997 Mar 15;47(6):618-21.
This article concentrates on the mechanisms by which viruses cause disease. Although the emphasis is on mechanisms rather than on a description of individual viral infections, selected viruses that best exemplify important or novel virus-host interactions are singled out. Twenty years ago, some viruses have helped understanding cell differentiation, and at present molecular and cellular biology are necessary to explain in depth the mechanisms of viral illnesses. Understanding and control of viral diseases are not mutually exclusive but rather simultaneous processes with multidisciplinary approaches. Like some bacterial toxins, virus may be deleterious without infecting cells. To use the cell machinery efficiently, viruses must be able to escape the immune system.
本文着重探讨病毒引发疾病的机制。尽管重点在于机制而非对个别病毒感染的描述，但仍挑选出了最能体现重要或新型病毒与宿主相互作用的特定病毒。二十年前，一些病毒有助于理解细胞分化，而如今分子生物学和细胞生物学对于深入解释病毒性疾病的机制是必不可少的。对病毒性疾病的理解和控制并非相互排斥，而是需要多学科方法同时进行的过程。与某些细菌毒素一样，病毒可能在不感染细胞的情况下具有有害性。为了有效地利用细胞机制，病毒必须能够逃避免疫系统。
