Effect of the sulfonylurea glyburide on superoxide dismutase in streptozotocin-induced diabetic rat muscle.
作者信息
Altan N, Yiğit S, Elmali E, Malhatun E, Rota S, Kiliç N
机构信息
Department of Biochemistry, Faculty of Medicine, University of Gazi, Beşevler, Ankara, Turkey.
出版信息
Gen Pharmacol. 1997 May;28(5):795-6. doi: 10.1016/s0306-3623(96)00355-2.
PMID:9184822
Abstract
- The effect of glyburide (glibenclamide) treatment on the muscle superoxide dismutase (SOD) activity of diabetic rats has been studied. 2. Four weeks of treatment with glyburide (5 mg/kg, orally) increased muscle SOD activity and decreased blood glucose levels. 3. The results of this study demonstrate that the sulfonylurea, glyburide, is capable of exerting direct insulin-like effects on muscle SOD activity in vivo.
摘要
Zotero 插件