Pfenninger M, Gruber U F
Schweiz Med Wochenschr. 1977 Sep 24;107(38):1335-8.
All studies on the value of acetylsalicylic acid for the prevention of postoperative thromboembolic complications have been evaluated. Controlled, prospective and randomized studies have been analyzed only where the incidence of postoperative deep vein thrombosis or pulmonary emboli was proven by objective diagnostic methods such as the fibrinogen test, phlebography or autopsy. In 6 studies there is no significant reduction in the incidence of deep vein thrombosis in general surgical and orthopedic patients after acetylsalicylic acid prevention. One study, though it has definite methodological defects, does suggest a significant reduction in the number of postoperative fatal pulmonary emboli in 120 patients with fractures of the upper end of the femur. On the basis of all these data, the prevention of postoperative thromboembolic complications by means of acetylsalicylic acid cannot be recommended.
所有关于乙酰水杨酸预防术后血栓栓塞并发症价值的研究均已得到评估。仅对那些通过客观诊断方法（如纤维蛋白原试验、静脉造影或尸检）证实术后深静脉血栓形成或肺栓塞发生率的对照、前瞻性和随机研究进行了分析。在6项研究中，乙酰水杨酸预防后，普通外科和骨科患者深静脉血栓形成的发生率没有显著降低。一项研究虽然存在明确的方法学缺陷，但确实表明，在120例股骨上端骨折患者中，术后致命性肺栓塞的数量显著减少。基于所有这些数据，不建议使用乙酰水杨酸预防术后血栓栓塞并发症。
