Roche J J, Cisneros G J, Acs G
Department of Dentistry, Montefiore Medical Center, Bronx, NY 10467, USA.
Angle Orthod. 1997;67(3):231-6. doi: 10.1043/0003-3219(1997)067<0231:TEOAOT>2.3.CO;2.
Orthodontic patients have reported the use of analgesics during therapy. However, common anti-inflammatory analgesics, such as aspirin and ibuprofen, have been shown to slow the rate of tooth movement. Acetaminophen, another common analgesic, does not possess anti-inflammatory properties. The effect of acetaminophen on tooth movement was studied using New Zealand white rabbits. Experimental animals were matched to a control animal of the same sex and weight. Under anesthesia, springs were ligated between the lower first molar and incisor, resulting in approximation of these teeth. Under blinded conditions, seven of the rabbits received 1000 mgs of acetaminophen daily. Seven control animals received water. The animals were sacrificed after 21 days. The movement of incisors and molars was measured. Results showed considerable movement within both the experimental and control groups, but no significant difference in tooth movement between them. Acetaminophen has no effect on the rate of tooth movement in rabbits undergoing orthodontic treatment.
正畸患者报告在治疗期间使用了镇痛药。然而，常见的抗炎镇痛药，如阿司匹林和布洛芬，已被证明会减缓牙齿移动的速度。对乙酰氨基酚是另一种常见的镇痛药，它不具备抗炎特性。使用新西兰白兔研究了对乙酰氨基酚对牙齿移动的影响。将实验动物与相同性别和体重的对照动物进行匹配。在麻醉状态下，在下颌第一磨牙和门牙之间结扎弹簧，使这些牙齿靠近。在盲法条件下，七只兔子每天接受1000毫克对乙酰氨基酚。七只对照动物接受水。21天后处死动物。测量门牙和磨牙的移动情况。结果显示实验组和对照组内均有明显移动，但两组之间牙齿移动无显著差异。对乙酰氨基酚对接受正畸治疗的兔子的牙齿移动速度没有影响。
