Nanni C
Washington Institute of Dermatologic Laser Surgery, Washington, DC, USA.
Dermatol Clin. 1997 Jul;15(3):521-34. doi: 10.1016/s0733-8635(05)70459-9.
Medical lasers have advanced so rapidly over the past 10 years that a thorough review of the complications of laser surgery must be based on fundamental laser physics in order to provide a general working framework of knowledge. New laser systems are being introduced and older systems have been improved, often making modern laser technology appear intimidating. In order to understand and even predict the side-effect profile of a specific laser, one must comprehend the principles on which the laser operates. The first medical lasers to be designed, continuous wave lasers, are effective but are extremely operator-dependent and can potentially result in a great deal of scarring. In 1983, the theory of selective photothermolysis was introduced that enabled physician-scientists to design lasers that were highly selective and safer to operate. Lasers designed on the theory of selective photothermolysis are capable of affecting a specific target tissue without a high risk of scarring and pigmentary changes. They accomplish this task by producing a wavelength and pulse duration that are best absorbed by a specific target. Not all modern lasers use selective photothermolysis and therefore may operate in either a continuous wave, quasi-continuous wave, pulsed, or Q quality-switched mode. Continuous wave lasers are least selective and tend to produce unwanted tissue damage and scarring through heat dissipation. Quasi-continuous wave lasers attempt to limit unwanted thermal damage by producing a series of brief laser pulses or by chopping a continuous wave beam; however, they still have a relatively high risk of causing nonspecific tissue damage and thermal injury. The pulsed and Q-switched systems adhere most closely to the laws of selective photothermolysis and result in the most selective destruction with the lowest risk of scarring and unwanted thermal diffusion. Of course, any laser system can potentially result in scarring and tissue damage; therefore, adequate operator education and skill are essential when using any medical laser.
在过去十年中,医用激光发展迅猛,因此对激光手术并发症进行全面回顾时,必须基于基础激光物理学知识,以提供一个通用的知识框架。新的激光系统不断推出,旧系统也得到改进,这常常使现代激光技术显得令人望而生畏。为了理解甚至预测特定激光的副作用情况,必须了解激光的工作原理。最早设计的医用激光——连续波激光,虽然有效,但对操作人员的依赖性极强,而且可能导致大量瘢痕形成。1983年,选择性光热作用理论被提出,这使得医学科学家能够设计出选择性高且操作更安全的激光。基于选择性光热作用理论设计的激光能够作用于特定目标组织,同时产生瘢痕和色素沉着变化的风险较低。它们通过产生特定目标最易吸收的波长和脉冲持续时间来完成这项任务。并非所有现代激光都采用选择性光热作用,因此可能以连续波、准连续波、脉冲或Q开关模式运行。连续波激光的选择性最低,往往会因热量散发而导致不必要的组织损伤和瘢痕形成。准连续波激光试图通过产生一系列短暂的激光脉冲或截断连续光束来限制不必要的热损伤;然而,它们导致非特异性组织损伤和热损伤的风险仍然相对较高。脉冲和Q开关系统最严格地遵循选择性光热作用规律,导致的破坏最具选择性,产生瘢痕和不必要的热扩散的风险最低。当然,任何激光系统都可能导致瘢痕形成和组织损伤;因此,在使用任何医用激光时,操作人员接受充分的培训并具备熟练的技能至关重要。