Pilger A, Germadnik D, Formanek D, Zwick H, Winkler N, Rüdiger H W
University Department of Occupational Medicine, Vienna General Hospital, Austria.
Eur J Appl Physiol Occup Physiol. 1997;75(5):467-9. doi: 10.1007/s004210050190.
The energy demand during physical exercise causes an increased oxygen uptake and supply to active tissues, which may increase the rate of free oxygen radical production and thereby affect the capacity of endogenous cellular defense systems. This could result in DNA base modifications, among which 8-hydroxydeoxyguanosine (8OHdG) is one of the most important and has widely been used as a biomarker of in vivo oxidative lesions. Therefore, we examined the effect of regular running exercise on the urinary levels of 8OHdG in 32 long-distance runners and in a group of untrained healthy subjects. The range of 8OHdG in urine was 0.12-6.45 mumol/mol creatinine in both groups, and no significant difference in the mean excretion levels between runners and control probands was observed. This gives no reason to believe that physical exercise in trained individuals may induce a disturbance of the oxidant-to-antioxidant balance.
体育锻炼期间的能量需求会导致活性组织的氧气摄取和供应增加，这可能会提高游离氧自由基的产生速率，从而影响内源性细胞防御系统的能力。这可能导致DNA碱基修饰，其中8-羟基脱氧鸟苷（8OHdG）是最重要的一种，并且已被广泛用作体内氧化损伤的生物标志物。因此，我们检测了32名长跑运动员和一组未经训练的健康受试者中，定期跑步锻炼对尿中8OHdG水平的影响。两组尿中8OHdG的范围均为0.12 - 6.45 μmol/mol肌酐，且未观察到跑步者与对照受试者之间的平均排泄水平有显著差异。这没有理由让人相信训练有素的个体进行体育锻炼会导致氧化还原平衡的紊乱。
