Poulsen H E, Loft S, Vistisen K
Department of Pharmacology, Panum Institute, Copenhagen University, Denmark.
J Sports Sci. 1996 Aug;14(4):343-6. doi: 10.1080/02640419608727720.
Extreme exercise increases oxygen uptake with a potential for increased formation of reactive oxygen species. Damage to biomolecules may occur if such an increase exceeds the protective capacity of antioxidant defence mechanisms. Vigorous exercise amounting to approximately 10 h a day for 30 days increased the rate of oxidative DNA modification by 33% (95% confidence limits, 3-67%; P < 0.02) in 20 men owing to the urinary excretion of 8-oxo-7,8-dihydro-2'-deoxyguanosine, an oxidatively modified deoxynucleoside originating from nuclear DNA repair, oxidation of the nucleotide pool from mitochondrial DNA and/or from cell turnover. Oxidative stress to DNA points to a risk for the development of cancer and premature ageing from extreme exercise.
剧烈运动可增加氧气摄取量，有可能增加活性氧的生成。如果这种增加超过抗氧化防御机制的保护能力，可能会对生物分子造成损害。20名男性连续30天每天进行约10小时的剧烈运动，由于8-氧代-7,8-二氢-2'-脱氧鸟苷的尿排泄，氧化DNA修饰率增加了33%（95%置信区间，3-67%；P<0.02），8-氧代-7,8-二氢-2'-脱氧鸟苷是一种氧化修饰的脱氧核苷，源于核DNA修复、线粒体DNA核苷酸池的氧化和/或细胞更新。DNA的氧化应激表明剧烈运动存在患癌症和过早衰老的风险。
