Zainudin Hakimi, Caszo Brinnell A, Knight Victor F, Gnanou Justin V
Centre for Research and Innovation Management, National Defence University of Malaysia, Kuala Lumpur, Malaysia.
School of Medicine, International Medical University, Kuala Lumpur, Malaysia.
Eurasian J Med. 2019 Jun;51(2):116-120. doi: 10.5152/eurasianjmed.2019.18106.
Regular moderate-intensity exercise has beneficial health effects, whereas regular strenuous exercise increases the production of oxidants that may lead to DNA, skeletal, and cardiac muscle damages. Triathletes experience strenuous muscular activity both during competition and training, being at risk of developing these tissue damages. The objective of the present study was to estimate DNA, skeletal, and cardiac muscle damages using blood biomarkers, 8-hydroxy-2'-deoxyguanosine (8-OHdG), myoglobin, and cardiac troponin I (cTnI) among young triathletes.
Age-matched seven male and seven female triathletes were recruited for the study. They were on a standardized training regimen and on average competed in at least one endurance event every month for the past 3-4 years. Serum biomarkers were measured using enzyme-linked immunosorbent assay at the start and at end of the racing season.
Both male and female triathletes showed a statistically significant increase in 8-OHdG. A similar pattern of increase was seen with serum myoglobin, which was not statistically significant in both male and female triathletes. cTnI levels did not show any change in both sexes.
Our study shows that there could be an increased evidence of DNA damage among triathletes. However, similar effects were not observed with skeletal and cardiac muscle biomarkers.
规律的中等强度运动对健康有益，而规律的剧烈运动则会增加氧化剂的产生，这可能导致DNA、骨骼和心肌损伤。铁人三项运动员在比赛和训练期间都会经历剧烈的肌肉活动，有发生这些组织损伤的风险。本研究的目的是使用血液生物标志物，即8-羟基-2'-脱氧鸟苷（8-OHdG）、肌红蛋白和心肌肌钙蛋白I（cTnI），来评估年轻铁人三项运动员的DNA、骨骼和心肌损伤情况。
招募了年龄匹配的7名男性和7名女性铁人三项运动员参与本研究。他们遵循标准化的训练方案，在过去3-4年中平均每月至少参加一次耐力赛事。在赛季开始和结束时，使用酶联免疫吸附测定法测量血清生物标志物。
男性和女性铁人三项运动员的8-OHdG均有统计学意义的显著增加。血清肌红蛋白也呈现出类似的增加模式，不过在男性和女性铁人三项运动员中均无统计学意义。cTnI水平在两性中均未显示出任何变化。
我们的研究表明，铁人三项运动员中可能有更多DNA损伤的证据。然而，在骨骼和心肌生物标志物方面未观察到类似影响。
