Gilland E, Hagberg H
Department of Obstetrics and Gynecology, Göteborg University, Sweden.
Neuroreport. 1997 May 6;8(7):1603-5. doi: 10.1097/00001756-199705060-00010.
Hypothermia after hypoxia-ischaemia (HI) confounds the interpretation of the effects of neuroprotective drug intervention. The effect of 0.5 mg/kg of dizocilpine (MK-801) administered after HI on rectal temperature at 2-36 h and on brain damage 2 weeks after the insult was evaluated in the immature rat. In pups kept at an ambient temperature of 21 degrees C, MK-801 lowered the temperature by 1.1 degrees C and reduced the brain damage by 45%. In pups held at an ambient temperature of 33 degrees C, MK-801 treatment afforded a 34% reduction of brain damage without lowering the rectal temperature. In conclusion, the neuroprotection offered by MK-801 does not depend on systemic hypothermia in this model.
缺氧缺血（HI）后的体温过低会混淆对神经保护药物干预效果的解读。在未成熟大鼠中评估了HI后给予0.5mg/kg地佐环平（MK-801）对2至36小时直肠温度以及损伤后2周脑损伤的影响。在环境温度保持在21摄氏度的幼崽中，MK-801使体温降低了1.1摄氏度，并使脑损伤减少了45%。在环境温度保持在33摄氏度的幼崽中，MK-801治疗使脑损伤减少了34%，而未降低直肠温度。总之，在该模型中，MK-801提供的神经保护并不依赖于全身性体温过低。
