Papa M, Sergeant J A, Sadile A G
Institute Human Anatomy, Second University of Naples (SUN), Italy.
Neuroreport. 1997 May 6;8(7):1607-12. doi: 10.1097/00001756-199705060-00011.
Transcription factors have been used as neuronal markers in the nucleus accumbens (ACB) of male juvenile spontaneously hypertensive rats (SHR), an animal model of attention-deficit hyperactivity disorder (ADHD), to trace putative neural substrates. In SHR, immunocytochemistry and PC-assisted image analysis showed lower expression of pan-fos, c-fos, zif/268 in the shell, and the c-fos and zif/268 in the core, with an increased level of Jun-B in the core. The differential lower basal expression of transcription factors in the ACB of an animal model of ADHD implies a reduced number of modules and might represent a neural substrate of the attention deficits seen in SHR and children with ADHD at low motivational levels.
转录因子已被用作雄性幼年自发性高血压大鼠（SHR）伏隔核（ACB）中的神经元标记物，SHR是注意力缺陷多动障碍（ADHD）的动物模型，用于追踪假定的神经基质。在SHR中，免疫细胞化学和计算机辅助图像分析显示，壳核中泛Fos、c-Fos、zif/268的表达较低，核心中c-Fos和zif/268的表达较低，而核心中Jun-B的水平升高。ADHD动物模型的ACB中转录因子的差异性较低基础表达意味着模块数量减少，可能代表了SHR和低动机水平的ADHD儿童中所见注意力缺陷的神经基质。
