Vergara M, Fraga X, Casellas F, Bermejo B, Malagelada J R
Service of Digestive Diseases, Vall d'Hebron General Hospital, Barcelona, Spain.
Rev Esp Enferm Dig. 1997 May;89(5):357-66.
Several epidemiological studies have suggested a possible seasonality in the presentation and course of inflammatory bowel disease. Our aim was to investigate whether in our area there is a seasonality in the presentation and evolution of inflammatory bowel disease. In this retrospective evaluation 255 patients were included, of whom 141 patients were diagnosed with ulcerative colitis and 114 with Crohn's disease according to conventional criteria, with histological confirmation in 225 patients. Relapse was defined as the development of symptoms that required an increase or change in the usual treatment. Periods of activity were related to the month and grouped within one of four seasonal periods: December to February, March to May, June to August and September to November. Bouts of ulcerative colitis and Crohn's disease were most frequently diagnosed in the period June to August (p < 0.05). Both diseases showed similar seasonality, and analysis of the 305 attacks did not show any significant trend. In conclusion, inflammatory bowel disease begins more frequently in the period June to August, but its course does not show consistent seasonal variations.
多项流行病学研究表明，炎症性肠病的发病及病程可能存在季节性。我们的目的是调查在我们地区炎症性肠病的发病及演变是否存在季节性。在这项回顾性评估中，纳入了255例患者，其中141例根据传统标准被诊断为溃疡性结肠炎，114例被诊断为克罗恩病，225例患者有组织学证实。复发被定义为出现需要增加或改变常规治疗的症状。活动期与月份相关，并分为四个季节期之一：12月至2月、3月至5月、6月至8月和9月至11月。溃疡性结肠炎和克罗恩病发作最常被诊断出是在6月至8月期间（p<0.05）。两种疾病表现出相似的季节性，对305次发作的分析未显示任何显著趋势。总之，炎症性肠病在6月至8月期间发病更为频繁，但其病程并未表现出一致的季节性变化。
