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对活细胞产生耐受的小鼠的免疫状态。III. 对耐受菌株具有细胞毒性的细胞的存在与演变。

Immune status of mice tolerant of living cells. III. Presence and evolution of cells cytotoxic to the tolerated strain.

作者信息

Oppenheim E S, Kinsky R, Voisin G A

出版信息

Transplantation. 1977 Oct;24(4):274-81. doi: 10.1097/00007890-197710000-00007.

Abstract

Spleen cells from CBA mice neonatally rendered highly tolerant to A/Jax (keeping a skin graft in perfect shape for more than 1 year and without detectable hemagglutinating or cytotoxic antibodies) contain cells cytotoxic for YAC 222 (A/Jax) in Cr release assay. The degree of the cytotoxicity depends on the age of the mouse, following a curve lower than, but parallel to, the one followed by the cytotoxicity of cells from CBA rendered immune by injecting them with A/Jax cells 1 week previously. The maximum of the cytotoxicity curve is reached during the 9th and 10th weeks. Normal CBA cells themselves are moderately cytotoxic to YAC 222. This "natural" cytotoxicity, significantly less intense and presumably directed against Moloney virus-related determinants, does not follow the same time pattern. The cytotoxic indices from both immune and tolerant cell populations are significantly reduced by CBA and anti-A/Jax immune serum. The tested sera of the tolerant mice did not contain hemagglutinating or in vitro-blocking antibodies in the Cr release assay (only the sera from unsuccessfully treated mice, having rejected their skin grafts, had some degree of blocking activity). However (and in agreement with previous experiments), these sera often contained synergistic hemagglutinins and in vivo enhancing properties of A/Jax tumors (Sal) grafted on CBA recipients.

摘要

新生期对A/Jax高度耐受的CBA小鼠的脾细胞(其皮肤移植片保持完美形态超过1年,且无可检测到的血凝或细胞毒性抗体)在铬释放试验中含有对YAC 222(A/Jax)具有细胞毒性的细胞。细胞毒性程度取决于小鼠的年龄,其曲线低于但平行于1周前通过注射A/Jax细胞而免疫的CBA小鼠细胞的细胞毒性曲线。细胞毒性曲线在第9周和第10周达到最大值。正常CBA细胞本身对YAC 222具有中等程度的细胞毒性。这种“天然”细胞毒性强度明显较低,推测针对莫洛尼病毒相关决定簇,其时间模式不同。CBA和抗A/Jax免疫血清可显著降低免疫和耐受细胞群体的细胞毒性指数。在铬释放试验中,耐受小鼠的测试血清不含血凝或体外阻断抗体(只有皮肤移植片被排斥的未成功治疗小鼠的血清具有一定程度的阻断活性)。然而(与先前实验一致),这些血清通常含有协同血凝素以及对移植到CBA受体上的A/Jax肿瘤(Sal)的体内增强特性。

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