Bravo M, Garcia-Anllo I, Baca P, Llodra J C
Department of Preventive Dentistry, School of Dentistry, University of Granada, Spain.
Community Dent Oral Epidemiol. 1997 Jun;25(3):247-50. doi: 10.1111/j.1600-0528.1997.tb00935.x.
The objective of this study was to compare Delton visible-light fissure sealant with Duraphat fluoride varnish in the prevention of occlusal caries in permanent first molars. A 48-month clinical trial was carried out in three groups of 6- to 8-year-old schoolchildren: a sealant group (104 children), in which Delton was used; a varnish group (112 children), in which Duraphat was used; and a control group (128 children). Sealant or varnish was applied to all sound permanent first molars, according to group. Replacement (sealant) and reapplication (varnish) was carried out every 6 months. A survival analysis was used to describe the molar failures over time in the three groups. A Cox proportional hazards regression model was built to test the influence of group on molar failure. The median survival times were 28.6 months for the control molars and more than 48 months for both sealed and varnished molars. The Cox model indicated a hazard ratio of 0.177 for the sealant vs control comparison, 0.463 for varnish vs control and 0.382 for sealant vs varnish.
本研究的目的是比较德尔顿可见光窝沟封闭剂与多乐氟氟保护漆预防恒牙第一磨牙咬合面龋的效果。对三组6至8岁学童进行了一项为期48个月的临床试验：使用德尔顿封闭剂的封闭剂组（104名儿童）；使用多乐氟的氟保护漆组（112名儿童）；以及对照组（128名儿童）。根据分组情况，将封闭剂或氟保护漆应用于所有健康的恒牙第一磨牙。每6个月进行一次更换（封闭剂）和重新涂抹（氟保护漆）。采用生存分析来描述三组中磨牙随时间的失败情况。建立了Cox比例风险回归模型来检验分组对磨牙失败的影响。对照组磨牙的中位生存时间为28.6个月，封闭和涂氟保护漆的磨牙中位生存时间均超过48个月。Cox模型显示，封闭剂与对照组比较的风险比为0.177，氟保护漆与对照组比较的风险比为0.463，封闭剂与氟保护漆比较的风险比为0.382。
