Ohtsuka S, Sugishita Y, Takeda T, Itai Y, Hyodo K, Ando M
Department of Cardiology, University of Tsukuba, Japan.
Jpn Circ J. 1997 May;61(5):432-40. doi: 10.1253/jcj.61.432.
We have developed dynamic intravenous coronary arteriography (IVCAG) using a monochromatic (33.3 keV), 2-dimensional X-ray beam (70 x 70 mm) generated from synchrotron radiation. To investigate its use to visualize the coronary arteries and to estimate coronary blood flow, we performed IVCAG in 10 dogs and 1 goat. The animals were irradiated with the synchrotron beam after intravenous injection of a contrast agent, and images were obtained using a TV camera and videorecorder. In the dogs, blood flow in the left anterior descending coronary artery (LAD) was also estimated from the images by applying a transit-time analysis. We obtained dynamic IVCAG images in the dogs and goat and could visualize even a deliberately created coronary stenosis about 1 mm in length. In addition, coronary blood flow could be estimated with an acceptable degree of accuracy. LAD flow calculated from IVCAG was 14.7 +/- 5.1 ml/min, whereas measured LAD flow was 16.6 +/- 4.8 ml/min. There was a close correlation between the estimated and measured LAD flows (r = 0.90, p < 0.01). Thus, dynamic IVCAG is minimally invasive, permits the simultaneous evaluation of coronary anatomy and blood flow, and may be feasible for clinical application.
我们利用同步辐射产生的单色（33.3 keV）二维X射线束（70×70 mm）开发了动态静脉冠状动脉造影（IVCAG）技术。为了研究其用于可视化冠状动脉和估计冠状动脉血流的情况，我们对10只狗和1只山羊进行了IVCAG检查。在静脉注射造影剂后，用同步辐射束对动物进行照射，并使用电视摄像机和录像机获取图像。在狗身上，还通过应用通过时间分析从图像中估计左前降支冠状动脉（LAD）的血流。我们在狗和山羊身上获得了动态IVCAG图像，甚至能够可视化人为制造的约1毫米长的冠状动脉狭窄。此外，冠状动脉血流可以以可接受的准确度进行估计。通过IVCAG计算的LAD血流为14.7±5.1 ml/min，而测量的LAD血流为16.6±4.8 ml/min。估计的和测量的LAD血流之间存在密切相关性（r = 0.90，p < 0.01）。因此，动态IVCAG微创，允许同时评估冠状动脉解剖结构和血流，并且可能在临床应用中可行。
