Rosen C J, Kessenich C R
Department of Nutrition, University of Maine, Bangor, USA.
Endocrinol Metab Clin North Am. 1997 Jun;26(2):295-311. doi: 10.1016/s0889-8529(05)70248-6.
Osteoporosis is one of the most common and debilitating diseases of postmenopausal women. Recent advances in understanding the bone remodeling unit have clarified the pathophysiologic processes that contribute to bone loss after the onset of estrogen deprivation. Epidemiologic studies have suggested a protective effect from long-term estrogen replacement therapy on fracture risk. This article examines the key role estrogens play in bone remodeling and the current evidence that estrogen treatment in postmenopausal women reduces the likelihood of osteoporotic fractures.
骨质疏松症是绝经后女性最常见且最具致残性的疾病之一。在理解骨重塑单元方面的最新进展，已阐明了雌激素缺乏后导致骨质流失的病理生理过程。流行病学研究表明，长期雌激素替代疗法对骨折风险具有保护作用。本文探讨了雌激素在骨重塑中所起的关键作用，以及目前关于绝经后女性雌激素治疗可降低骨质疏松性骨折可能性的证据。
