Bolekhan E A, Semenov D G, Gerasimova I A, Samoilov M O
Laboratory for the Regulation of Brain Neuron Function, I.P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg.
Neurosci Behav Physiol. 1997 May-Jun;27(3):268-71. doi: 10.1007/BF02462892.
The responses of cats with different levels of taste sensitivity to phenylthiocarbamide (PTC) bitters to five-minute hypoxia were studied; PTC sensitivity is a genetic marker of the activity of the cAMP system. Animals able to perceive PTC showed a number of functional differences, with higher levels of resistance to anoxia, than those which could not perceive PTC. The groups showed significant differences in the basal cAMP content in the cerebral cortex, and in the time course of changes in the cAMP level during anoxia and subsequent reoxygenation. It is suggested that these differences result from genetically determined features of the cAMP system, which is involved in forming adaptive responses.
研究了对苯硫脲（PTC）苦味有不同味觉敏感度水平的猫对五分钟缺氧的反应；PTC敏感性是环磷酸腺苷（cAMP）系统活性的遗传标记。能够感知PTC的动物表现出一些功能差异，对缺氧的耐受性水平高于无法感知PTC的动物。两组在大脑皮层中的基础cAMP含量以及缺氧和随后复氧过程中cAMP水平变化的时间进程方面存在显著差异。有人认为，这些差异是由cAMP系统的基因决定特征导致的，该系统参与形成适应性反应。
