Winet H, Bao J Y
J. Vernon Luck Sr. Orthopaedic Research Center, Orthopaedic Hospital, Los Angeles, CA 90007, USA.
J Biomater Sci Polym Ed. 1997;8(7):517-32. doi: 10.1163/156856297x00425.
Eroding poly(DL-lactide-co-glycolide) (PDLLG) washers and poly(L-lactide-co-glycolide) (PLLG) threads were observed chronically in vivo following loading in a bone chamber tibial implant (BCI). Images were recorded using intravital microscopy of the implanted rabbit. Erosion and bone healing, as represented by angiogenesis and osteogenesis, was determined from changes in projected area of observed polymer, vessels and bone, respectively. Erosion rates of the two polymers were significantly different. Healing adjacent to both polymers differed significantly from controls. Healing response to each polymer was also different, with the faster eroding PDLLG causing more deviation from normal osteogenesis and angiogenesis than did PLLG. It was speculated that the faster eroding polymer released macrophage-stimulating fragments earlier in the healing process, thus altering the normal macrophage-endothelial cell interaction which in turn affected angiogenesis-linked components of osteogenesis.
在骨腔胫骨植入物（BCI）中加载后，对体内长期观察到的可降解聚（DL-丙交酯-共-乙交酯）（PDLLG）垫圈和聚（L-丙交酯-共-乙交酯）（PLLG）缝线进行了研究。使用植入兔子的活体显微镜记录图像。分别根据观察到的聚合物、血管和骨骼投影面积的变化来确定以血管生成和成骨为代表的侵蚀和骨愈合情况。两种聚合物的侵蚀速率有显著差异。两种聚合物附近的愈合情况与对照组有显著差异。对每种聚合物的愈合反应也不同，侵蚀速度较快的PDLLG比PLLG导致更多偏离正常成骨和血管生成的情况。据推测，侵蚀速度较快的聚合物在愈合过程中更早地释放出刺激巨噬细胞的片段，从而改变了正常的巨噬细胞-内皮细胞相互作用，进而影响了与血管生成相关的成骨成分。
