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[可吸收接骨棒。聚乙交酯和聚(-L-丙交酯)各种接骨棒的生物力学及降解实验研究]

[Resorbable osteosynthesis rods. An experimental study of the biomechanics and degradation of various rods of polyglycolide and poly (-L-lactide)].

作者信息

Kunz E, Weckbach A, Rein S

机构信息

Chirurgische Universitätsklinik Würzburg.

出版信息

Unfallchirurgie. 1995 Feb;21(1):1-7. doi: 10.1007/BF02588345.

Abstract

Six different polyglycolide and poly(-L-lactide) rods were tested biomechanically: native, in vitro and in vivo. They were Biofix-C and Biofix-CG rods and 4 poly(-L-lactide) rods with a molecular weight between 70,000 and 700,000. Their flexual strength and elasticity module were determined by the 3-point flexion test. A total of 70 pins were implanted in the soft tissue and intramedullary to splint tibial osteotomies of 30 rabbits. The Biofix rods' flexural strength was high. There was no difference due to coating (346 to 402 N/mm2). In vitro experiments showed a rapid loss strength by 75 and 90%, equivalent to 2 to 3 weeks' implantation. The initial strength of the lactide pins was about 60% lower than that of the polyglycolid rods. The stability of the former after implantation decreased at a lower rate, with 25% of the initial strength being retained after 14 weeks. The histological findings were commensurate with the loss of flexural strength.

摘要

对六种不同的聚乙交酯和聚(L-丙交酯)棒进行了生物力学测试:包括天然的、体外和体内的。它们是Biofix-C和Biofix-CG棒以及4种分子量在70,000至700,000之间的聚(L-丙交酯)棒。通过三点弯曲试验测定它们的抗弯强度和弹性模量。总共70根钢针被植入30只兔子的软组织和骨髓腔内以固定胫骨截骨术。Biofix棒的抗弯强度很高。涂层之间没有差异(346至402牛/平方毫米)。体外实验表明强度迅速损失75%和90%,相当于植入2至3周的情况。丙交酯钢针的初始强度比聚乙交酯棒低约60%。前者植入后的稳定性下降速率较低,14周后保留了25%的初始强度。组织学结果与抗弯强度的损失相符。

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