Prieur A M, Dayer A, Roux-Lombard P, Dayer J M
Hôpital des Enfants Malades, Paris, France.
Clin Exp Rheumatol. 1997 Mar-Apr;15(2):211-4.
The levels of cytokines and of their inhibitors were assessed by ELISA in serum samples from 3 children with dermatomyositis (DM) and polymyositis (PM) who were followed for several years. We observed normal levels of IL-6 and TNF alpha, but increased concentrations of IL-1Ra and TNF-sR75 at disease onset, which was followed by a decrease in the levels of IL-1Ra and TNF-sR75 in the patients with a favorable disease outcome. In contrast, in the one patient who relapsed no correlation with the levels of cytokines or of their inhibitors could be established. These results suggest that cytokine inhibitors such as IL-1Ra and TNF-sR may be useful additional parameters for monitoring the evolution of DM and PM.
通过酶联免疫吸附测定法（ELISA）对3例患皮肌炎（DM）和多发性肌炎（PM）且已随访数年的儿童血清样本中的细胞因子及其抑制剂水平进行了评估。我们观察到，疾病发作时白细胞介素-6（IL-6）和肿瘤坏死因子α（TNFα）水平正常，但白细胞介素-1受体拮抗剂（IL-1Ra）和肿瘤坏死因子可溶性受体75（TNF-sR75）浓度升高，随后病情转好的患者体内IL-1Ra和TNF-sR75水平下降。相比之下，在1例复发患者中，未发现细胞因子或其抑制剂水平与之存在关联。这些结果表明，IL-1Ra和TNF-sR等细胞因子抑制剂可能是监测DM和PM病情发展的有用附加参数。
