Godfrey K M, Barker D J, Robinson S, Osmond C
Medical Research Council Environmental Epidemiology Unit (University of Southampton), Southampton General Hospital, UK.
Br J Obstet Gynaecol. 1997 Jun;104(6):663-7. doi: 10.1111/j.1471-0528.1997.tb11975.x.
To examine how maternal diet in pregnancy and parental body size and birthweight influence an infant's thinness at birth measured by a low ponderal index.
An observational study of newborn infants and their parents.
Southampton, England.
Five hundred and thirty-eight infants born at term.
Ponderal index at birth.
Women who had a high intake of carbohydrate in early pregnancy and a low intake of dairy protein in late pregnancy tended to have infants that were thin at birth (P = 0.01 and P = 0.03, respectively, in a simultaneous analysis). Women who themselves had a low birthweight also tended to have thin infants, ponderal index falling from 28.3 kg/m3 to 26.2 kg/m3 as the women's birthweights decreased from more than 4.0 kg to 2.5 kg or less (P < 0.0001). Tall fathers had thin infants, but ponderal index was not related to the women's heights or the fathers' birthweights.
These associations may reflect constraints on placental development imposed by a woman's nutrition in pregnancy and during her own intrauterine life. Effects of the father's height may be mediated through genetic influences on skeletal growth.
研究孕期母亲饮食、父母体型及出生体重如何影响通过低 ponderal 指数衡量的婴儿出生时的消瘦情况。
对新生儿及其父母进行的观察性研究。
英国南安普敦。
538 名足月出生的婴儿。
出生时的 ponderal 指数。
孕早期碳水化合物摄入量高且孕晚期乳类蛋白摄入量低的女性所生婴儿出生时往往较瘦（在同时分析中，P 值分别为 0.01 和 0.03）。自身出生体重低的女性所生婴儿也往往较瘦，随着女性出生体重从超过 4.0 千克降至 2.5 千克或更低，ponderal 指数从 28.3 千克/立方米降至 26.2 千克/立方米（P < 0.0001）。父亲身材高的婴儿较瘦，但 ponderal 指数与母亲身高或父亲出生体重无关。
这些关联可能反映了孕期女性营养及其自身子宫内生活对胎盘发育的限制。父亲身高的影响可能通过对骨骼生长的遗传影响来介导。
