Nakada T, Iijima M, Nakayama H, Maibach H I
Department of Dermatology, Showa University School of Medicine, Tokyo, Japan.
Contact Dermatitis. 1997 May;36(5):233-6. doi: 10.1111/j.1600-0536.1997.tb00207.x.
To evaluate the effect of ear piercing on sensitization to gold and other metals, diagnostic patch testing with 18 metals was performed. 377 patients (65 men and 312 women, ranging in age from 15 to 78 years; mean 34.2, S.D +/- 15.1 years) were patch tested; 107 had pierced earlobes. Metals were applied on the back for 2 days, and the results read with the ICDRG scoring system 3 days after application. Reactions of + to +3 were regarded as positive. There were significantly more patients reacting to gold chloride (p < 0.001), mercuric chloride and nickel sulfate (p < 0.05) in patients with pierced ears than in those without. Statistical issues included: (i) a significant number of patients with pierced ears referred because of earring dermatitis; (ii) those with pierced ears represented a different age group from those without; (iii) a significant number of patients without eczema in the non-pierced ear group. However, our data suggests that ear piercing is a risk factor not only for nickel but also for gold sensitization. Gold was the second most frequent metal allergen after nickel in the pierced group.
为评估穿耳洞对金及其他金属致敏的影响，对18种金属进行了诊断性斑贴试验。对377例患者（65名男性和312名女性，年龄15至78岁；平均34.2岁，标准差±15.1岁）进行了斑贴试验；其中107例有穿耳洞。将金属贴于背部2天，贴用后3天采用ICDRG评分系统读取结果。+至+3级反应视为阳性。穿耳洞患者对氯化金（p<0.001）、氯化汞和硫酸镍（p<0.05）发生反应的患者明显多于未穿耳洞者。统计学问题包括：（i）大量因耳环性皮炎而前来就诊的穿耳洞患者；（ii）穿耳洞者与未穿耳洞者代表不同年龄组；（iii）大量未穿耳洞组患者无湿疹。然而，我们的数据表明，穿耳洞不仅是镍致敏的危险因素，也是金致敏的危险因素。在穿耳洞组中，金是仅次于镍的第二常见金属过敏原。
