Oka K, Saito F, Yasuhara T, Sugimoto A
Department of Dermatology, Tokyo Hospital of Health Insurance Association of Nippon Express, Japan.
Contact Dermatitis. 1997 May;36(5):252-5. doi: 10.1111/j.1600-0536.1997.tb00212.x.
Dendropanax trifidus Makino (family Araliaceae, syn. Gilibertia trifida Makino) has been reported as causing allergic contact dermatitis in Japan. To identify the major allergen, fractionated extracts of fresh leaves of Dendropanax trifidus were patch tested on 2 patients with hypersensitivity to the plant. Cis-9,17-octadecadiene-12,14-diyne-1, 16-diol (I), an analog of falcarinol, was identified as an active component. 18 normal control subjects were patch tested with the leaf of Dendropanax trifidus and I diluted to 0.05% in pet. 4 of them showed active sensitization to the leaf of Dendropanax trifidus and I. Our results suggest that I is the major allergen of Dendropanax trifidus and is a strong sensitizer. The results of patch testing on patients and control subjects with the leaves of Fatsia japonica Decne. et Planch. and Hedera helix L., which also belong to the Araliaceae family, and urushiol are also shown.
裂叶楤木（五加科，同物异名：Gilibertia trifida Makino）在日本被报道可引起过敏性接触性皮炎。为鉴定主要过敏原，对2例对该植物过敏的患者进行了裂叶楤木新鲜叶片分级提取物的斑贴试验。顺式-9,17-十八碳二烯-12,14-二炔-1,16-二醇（I），一种法卡林二醇类似物，被鉴定为活性成分。18名正常对照受试者用稀释至0.05%（体积分数）的裂叶楤木叶和I进行斑贴试验。其中4人对裂叶楤木叶和I呈现出活性致敏反应。我们的结果表明I是裂叶楤木的主要过敏原，并且是一种强致敏原。还展示了对患者和对照受试者用同样属于五加科的八角金盘和常春藤的叶片以及漆酚进行斑贴试验的结果。
