Browne G, Jefferson J A, Wright G D, Hughes A E, Doherty C C, Nevin N C, Keogh J A
Renal Unit, Meath Hospital, Dublin, Ireland.
Nephrol Dial Transplant. 1997 Jun;12(6):1132-6. doi: 10.1093/ndt/12.6.1132.
Von Hippel Lindau disease is a dominantly inherited familial cancer syndrome, characterized by retinal, spinal, and cerebellar haemangioblastomas, renal cell carcinomas, and phaeochromocytomas. Cysts of the kidney and pancreas may also occur. We describe a large three-generation Irish family with VHL disease who initially presented with features typical of autosomal dominant polycystic kidney disease. Eight clinically affected individuals were found. Visceral complications were particularly prominent within the family. There were no cases of retinal angiomata or phaeochromocytoma. The diagnosis was confirmed by genetic linkage analysis in this family, although the exact mutation has yet to be defined.
