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衰老过程中椎间盘及小关节的矿物质变化

[Mineral changes in the intervertebral disc and facet joints during aging].

作者信息

Niedźwiedzki T, Pawlikowski M, Brudnicki J, Palka E

机构信息

Oddziału Urazowo-Ortopedycznego WSS w Krakowie.

出版信息

Chir Narzadow Ruchu Ortop Pol. 1997;62(1):39-45.

PMID:9198545
Abstract

The mineralogic examinations of intervertebral disc and cartilages of facet joints, taken from corps of the accidents victims, from the level L4-L5, were performed. At the moment of accident the middle age of victim was 41.2 years (4-87 years). Scanning microscopy, atom absorption, chemical analyses and electron microprobe analyses were used in the examinations. As the result of examinations we found: demineralisation of nucleus pulposus in the intervertebral disc and two kinds of mineralisation of anulus fibrosus--invisible and visible. Invisible mineralization was found as the initial stage of visible mineralization. In the cartilages of fact joints, similarly as in the anulus fibrosus, the visible mineralization was found, characterised by the presence of the different shaped mineral deposits in the microscope. The invisible mineralization characterised by increased content of Ca and P and by changes in the chemical composition of basic cartilage substance Fe, Cu, Pb, Zn, Sr, Na, K. It was detected with very sensitive methods. The very close relations between mineralogic changes in the intervertebral disc and facet joints cartilages were also found. Mineralogic changes in degenerative changes of vertebral column outstrip the radiologic ones.

摘要

对从事故受害者尸体L4 - L5水平获取的椎间盘和小关节软骨进行了矿物学检查。事故发生时受害者的平均年龄为41.2岁(4 - 87岁)。检查中使用了扫描显微镜、原子吸收、化学分析和电子微探针分析。检查结果如下:椎间盘髓核脱矿,纤维环有两种矿化——不可见矿化和可见矿化。不可见矿化是可见矿化的初始阶段。在小关节软骨中,与纤维环一样,发现了可见矿化,其特征是在显微镜下存在不同形状的矿物质沉积物。不可见矿化的特征是钙和磷含量增加以及基本软骨物质中铁、铜、铅、锌、锶、钠、钾的化学成分变化。这是用非常灵敏的方法检测到的。还发现了椎间盘和小关节软骨的矿物学变化之间非常密切的关系。脊柱退行性变化中的矿物学变化超过了放射学变化。

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