Irander K, Ståhlbom B, Welinder H, Akesson B
Department of Otorhinolaryngology, University Hospital, Linköping, Sweden.
Acta Otolaryngol. 1997 May;117(3):433-6. doi: 10.3109/00016489709113417.
Six healthy non-atopic male volunteers participated in a dose-response study of N,N-dimethylbenzylamine (DMBA), which is a reactive chemical used in epoxy systems. The effects on the nasal mucosa after inhalation of 0, 20, 45, 80 and 120 microg/m3 were studied by means of symptom recordings, acoustic rhinometry, nasal lavages and nasal cytology processed for light microscopy of metachromatic cells (MC) and eosinophils (EOS). Although only minor symptoms were provoked, the numbers of MC and Eos tended to increase in a dose-response fashion after inhalation of the chemical. No signs of degranulation of the cells were found, as the levels of tryptase and eosinophil cationic protein in the nasal lavages remained low at all DMBA exposure levels. We therefore conclude that a reactive chemical such as DMBA can influence MC and Eos in the nasal mucosa even at low dose levels without causing significant clinical symptoms.
六名健康的非特应性男性志愿者参与了一项关于N,N-二甲基苄胺（DMBA）的剂量反应研究，DMBA是一种用于环氧体系的活性化学品。通过症状记录、鼻声反射测量、鼻腔灌洗以及对经处理用于异染细胞（MC）和嗜酸性粒细胞（EOS）光学显微镜检查的鼻腔细胞学分析，研究了吸入0、20、45、80和120微克/立方米该化学品后对鼻黏膜的影响。尽管仅引发了轻微症状，但吸入该化学品后，MC和EOS的数量呈剂量反应性增加趋势。由于在所有DMBA暴露水平下鼻腔灌洗液中类胰蛋白酶和嗜酸性粒细胞阳离子蛋白水平均保持较低，未发现细胞脱颗粒迹象。因此，我们得出结论，像DMBA这样的活性化学品即使在低剂量水平下也能影响鼻黏膜中的MC和EOS，而不会引起明显的临床症状。
