Pazdrak K, Górski P, Krakowiak A, Ruta U
Department of Occupational Diseases, Institute of Occupational Medicine, Lódź, Poland.
Int Arch Occup Environ Health. 1993;64(7):515-9. doi: 10.1007/BF00381101.
The aim of the study was to characterize the nature of the formaldehyde-induced nasal response consisting in symptoms of rhinitis and changes in nasal lavage fluid. Eleven healthy subjects and nine patients with specific skin sensitization were provoked in a toxicological chamber with formaldehyde at a dose of 0.5 mg/m3 over 2 h. Nasal lavage was performed prior to and immediately after provocation and 4 and 18 h later. Provocation with formaldehyde caused transient symptoms of rhinitis and prolonged changes in nasal washings. There were increases in the number and proportion of eosinophils and elevated albumin and total protein levels in nasal lavage fluid 4 and 18 h after provocation. No difference in the nasal response to formaldehyde was found between patients with skin sensitization and healthy subjects. These data confirm the irritative effects of formaldehyde and are also suggestive of nonspecific proinflammatory properties when formaldehyde is inhaled at a low (0.5 mg/m3) dose.
本研究的目的是描述由甲醛诱发的鼻部反应的性质，该反应包括鼻炎症状和鼻灌洗液的变化。在毒理学实验舱中，对11名健康受试者和9名有特异性皮肤致敏的患者用剂量为0.5毫克/立方米的甲醛进行2小时激发。在激发前、激发后即刻以及4小时和18小时后进行鼻灌洗。甲醛激发引起了短暂的鼻炎症状以及鼻冲洗液的长期变化。激发后4小时和18小时，鼻灌洗液中嗜酸性粒细胞数量和比例增加，白蛋白和总蛋白水平升高。皮肤致敏患者和健康受试者对甲醛的鼻部反应未发现差异。这些数据证实了甲醛的刺激作用，也表明在低剂量（0.5毫克/立方米）吸入甲醛时具有非特异性促炎特性。
