[精神分裂症患者血清对PHA刺激的淋巴细胞培养物中DNA合成的影响]
[Effect of schizophrenic patients' serum on DNA synthesis in cultures of PHA stimulated lymphocytes].
作者信息
Pivovarova A I, Maznina T P
出版信息
Zh Nevropatol Psikhiatr Im S S Korsakova. 1977;77(9):1357-60.
The authors studied the influence of the blood sera of schizophrenic patients on the DNA synthesis in a PHA stimulated lymphocyte culture of normal donors. It was established that in 13 of the 15 studied patients the blood sera contained factors, inhibiting the DNA synthesis in lymphocytes in normals. The reactivity of lymphocytes on the PHA was in an inverse correlation with the figure of the cytotoxic index. The assumption is being made that the inhibiting action of the serum is conditioned by the presence of antibodies to thymocytes and T-lymphocytes.
作者研究了精神分裂症患者血清对正常供体PHA刺激的淋巴细胞培养物中DNA合成的影响。结果表明，在15例研究患者中的13例，其血清中含有抑制正常人淋巴细胞DNA合成的因子。淋巴细胞对PHA的反应性与细胞毒性指数呈负相关。据推测，血清的抑制作用是由抗胸腺细胞和T淋巴细胞抗体的存在所决定的。
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