[血清体液因子——精神分裂症患者外周血淋巴细胞生理状态改变的原因]
[Serum humoral factors--cause of the altered physiologic state of peripheral blood lymphocytes in schizophrenic patients].
作者信息
Lideman R R, Babaian N G
出版信息
Biull Eksp Biol Med. 1976 Sep;82(9):1047-50.
Statistically significant correlations were revealed between the following: the percentage content in the lymphocyte cultures of patients suffering from schizophrenia of cells responding to stimulation with phytohemagglutinin (PHA) by DNA synthesis, and the percentage in the white blood cell cultures of healthy donors of lymphocytes failing to respond to the PHA stimulation by the DNA synthesis as a result of cultivation of these cells in a medium containing the blood serum (20%) of schizophrenic patients. Similar correlation was revealed between the percentage content in cultures of the white blood cells of schizophrenic patients of adhesive lymphocytes and the percentage of adhesive lymphocytes in the white blood cell cultures of healthy donors in cultivation of these cells in a medium containing the blood serum (20%) of schizophrenic patients. The data obtained confirmed a supposition that the altered physiological condition of the peripheral blood lymphocytes of patients suffering from schizophrenia was caused by the factors contained in the blood serum of these patients.
在以下各项之间发现了具有统计学意义的相关性
精神分裂症患者淋巴细胞培养物中通过DNA合成对植物血凝素（PHA）刺激作出反应的细胞的百分比含量，以及健康供体白细胞培养物中由于在含有精神分裂症患者血清（20%）的培养基中培养这些细胞而未能通过DNA合成对PHA刺激作出反应的淋巴细胞的百分比。在精神分裂症患者白细胞培养物中黏附淋巴细胞的百分比含量与健康供体白细胞培养物中在含有精神分裂症患者血清（20%）的培养基中培养时黏附淋巴细胞的百分比之间也发现了类似的相关性。所获得的数据证实了一种假设，即精神分裂症患者外周血淋巴细胞生理状态的改变是由这些患者血清中所含的因素引起的。
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