[精神分裂症患者外周血淋巴细胞的增殖反应]

[Proliferative response of schizophrenic patient's peripheral blood lymphocytes].

作者信息

Fetisova T K

出版信息

Zh Nevropatol Psikhiatr Im S S Korsakova. 1978;78(6):867-71.

Abstract

The author studied the proliferative abilities of lymphocytes in the peripheral blood of schizophrenic patients and normals in cultures not containing autologous plasma. The reactivity of lymphocytes in schizophrenic patients to PHA and rabbit serum to human thymocytes (ATS) appeared to be decreased. The level of their proliferative response to concavaline A was significantly the same as in normals. The assumption is made that in schizophrenic patients there is a blocking of lymphocyte receptors, binding PHA and ATS. The possibility of a deficit of a subpopulation of T lymphocytes in the organism of patients highly sensitive to stimulation by PHA and ATS is not excluded.

摘要

作者研究了精神分裂症患者和正常人外周血淋巴细胞在不含自身血浆的培养物中的增殖能力。精神分裂症患者淋巴细胞对PHA和兔抗人胸腺细胞血清（ATS）的反应性似乎降低。他们对刀豆蛋白A的增殖反应水平与正常人显著相同。据推测，精神分裂症患者存在淋巴细胞受体的阻断，这些受体可结合PHA和ATS。不排除患者机体中对PHA和ATS刺激高度敏感的T淋巴细胞亚群存在缺陷的可能性。

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