Riddington L, Hall A J, Tait B, Nicholson I, Varney M
Royal Melbourne Hospital, Parkville, Victoria.
Aust N Z J Ophthalmol. 1996 May;24(2):147-9. doi: 10.1111/j.1442-9071.1996.tb01570.x.
Vogt-Koyanagi-Harada syndrome (VKH), is an idiopathic, multisystem inflammatory disorder primarily involving the eye. HLA typing has shown a strong association between the HLA-DR4 antigen and people of Japanese, Han Chinese and Hispanic ancestry with VKH. This study reviewed the clinical features and HLA typing of Vietnamese patients with VKH.
A retrospective review of four unrelated Vietnamese patients with VKH seen in private practice and hospital clinic. The American Uveitis Society (1978) criteria for VKH diagnosis were satisfied. Standard microcytotoxic assays for Class I antigens and HLA-DNA typing of Class II DR antigens (DRB1 genotyping) by the PCR-SSO method were performed.
The clinical features of VKH in Vietnamese were comparable to those seen in other Asian races. HLA-DR4 was present in three of the four VKH patients. Two of these patients also expressed the allele DRB1*0405.
The strong association between HLA-DR4 and the DRB1*0405 allele and VKH seen in Japanese people, may well also exist in Vietnamese people. The HLA association suggests an immunogenetic predisposition to VKH.
伏格特-小柳-原田综合征（VKH）是一种特发性多系统炎症性疾病，主要累及眼部。HLA分型显示，HLA-DR4抗原与日本、汉族和西班牙裔血统的VKH患者密切相关。本研究回顾了越南VKH患者的临床特征和HLA分型。
对在私人诊所和医院门诊就诊的4例无血缘关系的越南VKH患者进行回顾性研究。符合美国葡萄膜炎学会（1978年）的VKH诊断标准。采用标准微量细胞毒试验检测I类抗原，并通过PCR-SSO方法对II类DR抗原（DRB1基因分型）进行HLA-DNA分型。
越南VKH患者的临床特征与其他亚洲种族相似。4例VKH患者中有3例存在HLA-DR4。其中2例患者还表达了DRB1*0405等位基因。
HLA-DR4与DRB1*0405等位基因和VKH之间的密切关联在日本人中可见，在越南人中可能也存在。HLA关联提示VKH存在免疫遗传易感性。
