Paemen L, Jansen P M, Proost P, Van Damme J, Opdenakker G, Hack E, Taylor F B
Rega Institute for Medical Research, University of Leuven, Belgium.
Cytokine. 1997 Jun;9(6):412-5. doi: 10.1006/cyto.1996.0183.
Intravenous injection of sublethal or lethal doses of Escherichia coli in baboons resulted in increased serum levels of the matrix metalloprotease gelatinase B and the chemokine monocyte chemotactic protein 2 (MCP-2). In both animal models, gelatinase B appeared faster than MCP-2. After sublethal challenge, serum levels of gelatinase B and MCP-2 were found to be correlated, reaching peak levels between 2 and 4 h after bacterial challenge. After lethal challenge, however, MCP-2 tended to increase until 10 h. The kinetics of appearance suggest induction of release of gelatinase B and de novo synthesis and secretion of MCP-2, both by endotoxin.
在狒狒体内静脉注射亚致死剂量或致死剂量的大肠杆菌，会导致血清中基质金属蛋白酶明胶酶B和趋化因子单核细胞趋化蛋白2（MCP - 2）的水平升高。在这两种动物模型中，明胶酶B比MCP - 2出现得更快。在亚致死性攻击后，发现明胶酶B和MCP - 2的血清水平具有相关性，在细菌攻击后2至4小时达到峰值水平。然而，在致死性攻击后，MCP - 2的水平倾向于持续升高直至10小时。其出现的动力学表明，内毒素可诱导明胶酶B的释放以及MCP - 2的从头合成和分泌。
