Jansen P M, van Damme J, Put W, de Jong I W, Taylor F B, Hack C E
Central Laboratory of The Netherlands Red Cross Blood Transfusion Service, University of Amsterdam.
J Infect Dis. 1995 Jun;171(6):1640-2. doi: 10.1093/infdis/171.6.1640.
The chemokine monocyte chemotactic protein 1 (MCP-1) is a cytokine with chemotactic activity specific for mononuclear phagocytes. To investigate the possible involvement of MCP-1 in the pathogenesis of sepsis, its course was studied in baboons challenged intravenously with a sublethal or lethal dose of Escherichia coli. Levels of MCP-1 started to increase in both groups of animals 2 h after injection of E. coli, reaching peak levels 4 and 6 h after a sublethal (186 +/- 21 ng/mL) or a lethal (213 +/- 24 ng/mL) dose, respectively. Levels of MCP-1 correlated significantly with plasma levels of another chemokine, interleukin-8 (IL-8; r = .826. P < .001), suggesting that common stimuli mediate the release of both cytokines in this model.
趋化因子单核细胞趋化蛋白1（MCP-1）是一种对单核吞噬细胞具有特异性趋化活性的细胞因子。为了研究MCP-1在脓毒症发病机制中可能的作用，在静脉注射亚致死剂量或致死剂量大肠杆菌的狒狒身上研究了其变化过程。在注射大肠杆菌后2小时，两组动物体内的MCP-1水平均开始升高，在亚致死剂量（186±21 ng/mL）或致死剂量（213±24 ng/mL）注射后4小时和6小时分别达到峰值水平。MCP-1水平与另一种趋化因子白细胞介素-8（IL-8）的血浆水平显著相关（r = 0.826，P < 0.001），表明在该模型中共同的刺激介导了这两种细胞因子的释放。
