Gastrointestinal Research Unit of Departments of Gastroenterology, University Medical Center Utrecht, Utrecht, The Netherlands.
Dig Dis Sci. 2010 Mar;55(3):716-23. doi: 10.1007/s10620-009-0765-9. Epub 2009 Mar 3.
Intestinal permeability and the effect of NSAIDs on permeability were investigated in 14 irritable bowel syndrome (IBS) patients and 15 healthy subjects. In the study, 24-h urinary recoveries of orally administered polyethylene glycols (PEGs 400, 1500, and 4000) were not significantly different in healthy subjects and IBS patients before or after NSAID ingestion. Lactulose mannitol ratios in healthy subjects and IBS patients were not significantly different. Only time-dependent monitoring of PEG excretion showed that NSAIDs enhanced intestinal permeability for PEG 4000 in healthy subjects (P = 0.050) and for PEGs 400, 1500, and 4000 in IBS patients (P = 0.012, P = 0.041, and P = 0.012, respectively). These results show that intestinal permeability in IBS patients is not different from that in healthy subjects; NSAIDs compromise intestinal permeability in IBS patients to a greater extent than in healthy subjects, which suggests that IBS is associated with an altered response of the intestinal barrier to noxious agents.
肠通透性和 NSAIDs 对通透性的影响在 14 例肠易激综合征 (IBS) 患者和 15 例健康受试者中进行了研究。在这项研究中，在 NSAID 摄入前后，健康受试者和 IBS 患者口服给予的聚乙二醇 (PEG) 400、1500 和 4000 的 24 小时尿回收率没有明显差异。健康受试者和 IBS 患者的乳果糖甘露醇比值没有明显差异。只有 PEG 排泄的时间依赖性监测显示，NSAIDs 增强了健康受试者中 PEG 4000 的肠通透性 (P = 0.050)，以及 IBS 患者中 PEG 400、1500 和 4000 的肠通透性 (P = 0.012、P = 0.041 和 P = 0.012)。这些结果表明，IBS 患者的肠通透性与健康受试者没有差异；与健康受试者相比，NSAIDs 对 IBS 患者的肠通透性造成更大的损害，这表明 IBS 与肠道屏障对有害物的反应改变有关。
