Guitton J, Désage M, Alamercery S, Dutruch L, Dautraix S, Perdrix J P, Brazier J L
Laboratoire d'Etudes Analytiques et Cinétiques du Médicament, Institut des Sciences Pharmaceutiques et Biologiques de Lyon, France.
J Chromatogr B Biomed Sci Appl. 1997 May 23;693(1):59-70. doi: 10.1016/s0378-4347(97)00050-9.
Fentanyl, a synthetic opioid, undergoes important biotransformation to several metabolites. A gas chromatographic-mass spectrometric assay was applied for the simultaneous analysis of fentanyl and its major metabolites in biological samples. The identification of different metabolites was performed by gas chromatography-mass spectrometry (electronic impact and chemical ionisation modes) and gas chromatography-Fourier transform infrared spectroscopy. In the present study, rat and human microsomes incubation mixtures and human urines were analysed. In vitro formation of already known fentanyl metabolites was confirmed. The presence of metabolites not previously detected in human urine is described.
芬太尼是一种合成阿片类药物，会经过重要的生物转化形成多种代谢产物。采用气相色谱 - 质谱分析法对生物样品中的芬太尼及其主要代谢产物进行同步分析。通过气相色谱 - 质谱法（电子轰击和化学电离模式）以及气相色谱 - 傅里叶变换红外光谱法对不同代谢产物进行鉴定。在本研究中，分析了大鼠和人的微粒体孵育混合物以及人的尿液。已确认了已知芬太尼代谢产物的体外形成情况。描述了此前未在人尿液中检测到的代谢产物的存在情况。
